Parameter
| Biomarker | TIMP | Full name | Transforming growth factor-beta 1, Tissue inhibitor of metalloproteinase-1 | Molecular Type | Proteins (cytokines/inhibitors) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Fibrosis monitoring and prognosis | ||
| Disease | Chronic pancreatitis (CP) | Disease Subtypes | / | ||
| Organ | Pancreas | Test Sample / Technology Platform | Serum (ELISA, immunoassay) | ||
| Pathobiological Mechanisms | TGF-β1 promotes the activation of pancreatic stellate cells and collagen deposition, and TIMP-1 inhibits matrix degradation, which jointly promote pancreatic fibrosis | ||||
| Clinical Availability Status | Clinical research phase: positively correlated with the degree of CP fibrosis, used to assess the progression of fibrosis | ||||
| Notes and Dynamics | It is a core marker reflecting the fibrosis process of CP, which can be used to screen patients with high fibrosis risk and guide anti-fibrosis treatment | ||||