Human Biomarker Navigator is not only a comprehensive data repository, but also an intelligent retrieval and analysis platform designed for researchers and clinicians to systematically explore human health-related biomarkers. It enables in-depth study of biomarkers across multiple dimensions, including detailed molecular profiling, disease associations, organ specificity, and clinical relevance.For each biomarker—such as the TP53 mutation illustrated in the example—our platform displays a structured profile encompassing:•Biomarker Identity: name, full name, molecular type, and molecular weight•Functional Dimensions: core roles in diagnosis, prognosis, or therapeutic guidance•Disease Context: associated diseases (e.g., Acute Myeloid Leukemia) and subtypes•Organ & Sample Information: related organs (e.g., blood, bone marrow) and recommended test samples or technology platforms (e.g., whole blood/genomic sequencing)•Pathobiological Mechanisms: description of the biological dysfunction cau...

Throughout the lifespan, environmental exposures, lifestyle, infections, chronic inflammation, metabolic remodeling, and aging continuously influence the human body. Changes in barrier integrity, circadian rhythm, immune balance, metabolic flexibility, and neurocognitive function collectively shape the dynamic transition from health to subhealth and disease. Because many chronic diseases develop gradually and may remain clinically silent for years, biomarkers provide an important means of identifying early biological changes, assessing risk, monitoring disease progression, and supporting preventive health management.This website provides a systematic resource for exploring biomarkers across the health–disease continuum. It integrates biomarkers from multiple modalities, including nucleic acids and epigenetic modifications, proteins and cytokines, metabolites, microbiota, exosomes, imaging features, electrophysiological signals, clinical functional indicators, and other emerging digital...