Parameter
| Biomarker | PRSS1, SPINK1, CTRC, CPA1 | Full name | Protease serine 1, Serine peptidase inhibitor Kazal type 1, Chymotrypsin C, Carboxypeptidase A1 | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Susceptibility, risk assessment | ||
| Disease | Chronic pancreatitis (CP) | Disease Subtypes | / | ||
| Organ | Pancreas | Test Sample / Technology Platform | Whole blood (genotyping, sequencing) | ||
| Pathobiological Mechanisms | PRSS1 mutations lead to abnormal activation of trypsin, SPINK1 mutations lose the inhibitory function of trypsin, CTRC and CPA1 mutations affect pancreatic enzyme processing, and all increase the risk of CP | ||||
| Clinical Availability Status | Clinical available (risk assessment) : conventional genetic tests available, for familial CP screening and risk prediction | ||||
| Notes and Dynamics | Is the core of the CP genetic susceptibility gene detects targets, can be used for screening high-risk group, guide lifestyle intervention to prevent the disease | ||||