Parameter
| Biomarker | FLC | Full name | Serum free light chains(involved/uninvoloved) | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | diagnosis, therapeutic efficacy monitoring, prognosis | ||
| Disease | Multiple Myeloma (MM) | Disease Subtypes | / | ||
| Organ | Bone marrow, Kidney | Test Sample / Technology Platform | serum | ||
| Pathobiological Mechanisms | Abnormal clonal plasma cells secrete monoclonal free light chains, which deposit in the kidneys and cause damage; the abnormal ratio s1158uggests clonal proliferation. | ||||
| Clinical Availability Status | International Myeloma Working Group (IMWG) | ||||
| Notes and Dynamics | Core monitoring indicators for non-secretory multiple myeloma (MM); elevated free lymphocyte count (FLC) alone is more sensitive than serum M protein and can predict early recurrence; persistent abnormal FLC ratio significantly shortens progression-free survival. | ||||