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Parameter
Biomarker COMP Full name serum chondrocyte oligomeric matrix protein Molecular Type chondroitin
Molecular Formula Molecular Weight Core Functional Dimensions Early diagnosis and post-traumatic cartilage injury monitoring
Disease Osteoarthritis (OA) Disease Subtypes /
Organ Joint (Cartilage) Test Sample / Technology Platform Serum (ELISA, immunoturbidimetry)
Pathobiological Mechanisms Abnormal cartilage repair after trauma, with COMP released into the bloodstream and elevated levels indicating increased risk of cartilage injury
Clinical Availability Status Clinical trials
Notes and Dynamics atients with elevated serum COMP levels within 1 month post-trauma have a 2-fold increased risk of developing osteoarthritis within 2 years.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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