Parameter
| Biomarker | TNF-α | Full name | Tumor necrosis factor-α | Molecular Type | cell factor |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Inflammation assessment and treatment response prediction | ||
| Disease | Osteoarthritis (OA) | Disease Subtypes | / | ||
| Organ | Joint (Synovium) | Test Sample / Technology Platform | Synovial fluid (ELISA, immunoblotting) | ||
| Pathobiological Mechanisms | Mediates chronic intra-articular inflammation, promotes cartilage degradation and bone erosion, with a positive correlation between the degree of inflammation and the horizontal extent. | ||||
| Clinical Availability Status | In research | ||||
| Notes and Dynamics | Anti-TNF-α therapy can reduce the level of TNF-α in synovial fluid and improve patient symptoms, serving as an efficacy monitoring indicator. | ||||