Parameter
| Biomarker | TP53 mut | Full name | TP53 mutation | Molecular Type | nucleic acid |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Prognostic stratification and risk assessment | ||
| Disease | Osteosarcoma (OS) | Disease Subtypes | / | ||
| Organ | Bone | Test Sample / Technology Platform | Tumor tissue, ctDNA (NGS, Sanger sequencing) | ||
| Pathobiological Mechanisms | Inactivation of tumor suppressor genes leads to uncontrolled cell cycle and resistance to apoptosis | ||||
| Clinical Availability Status | Available at some clinical centers | ||||
| Notes and Dynamics | Li-Fraumeni syndrome is highly prevalent, with a mutation rate of 90%, indicating an aggressive phenotype. | ||||