Parameter
| Biomarker | MDM2，CDK4 amplification | Full name | MDM2 amplification, CDK4 amplification | Molecular Type | nucleic acid |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, differentiation, and prognosis assessment | ||
| Disease | Osteosarcoma (OS) | Disease Subtypes | / | ||
| Organ | Bone | Test Sample / Technology Platform | Tumor tissue (FISH、IHC) | ||
| Pathobiological Mechanisms | Drive abnormal progression of the cell cycle, distinguishing benign bone lesions from low-grade OS | ||||
| Clinical Availability Status | Clinically available (pathological differentiation) | ||||
| Notes and Dynamics | High specificity, with a positive rate>80% in low-grade OS, indicating relatively favorable prognosis | ||||