Parameter
| Biomarker | ABCB1 (P-gp) | Full name | ATP-binding cassette subfamily B member 1 | Molecular Type | membranin |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Drug resistance prediction, therapeutic targets | ||
| Disease | Osteosarcoma (OS) | Disease Subtypes | / | ||
| Organ | Bone | Test Sample / Technology Platform | Tumor tissue (IHC, flow cytometry) | ||
| Pathobiological Mechanisms | Drug efflux pump, reducing intracellular chemotherapy drug concentration | ||||
| Clinical Availability Status | Clinically available (drug resistance assessment) | ||||
| Notes and Dynamics | Patients with high expression exhibit a 30% or greater increase in resistance to doxorubicin and cisplatin. | ||||