Parameter
| Biomarker | BALP | Full name | Serum bone-specific alkaline phosphatase | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Bone formation assessment | ||
| Disease | Osteoporosis (OP) | Disease Subtypes | / | ||
| Organ | Bone | Test Sample / Technology Platform | Serum (Enzyme-Linked Immunosorbent Assay (ELISA), Chemiluminescence Assay) | ||
| Pathobiological Mechanisms | Secreted by osteoblasts, it catalyzes bone matrix mineralization. Elevated levels reflect enhanced osteoblast activity and may early indicate abnormal bone formation. | ||||
| Clinical Availability Status | Widely available | ||||
| Notes and Dynamics | It was negatively correlated with lumbar BMD, and combined with PINP, the diagnostic sensitivity of postmenopausal osteoporosis was improved to 82%; A decline of ≥40% indicates efficacy of anti-osteoporosis therapy | ||||