Parameter
| Biomarker | PINP | Full name | Serum type I procollagen N-terminal prepeptide | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Bone formation monitoring | ||
| Disease | Osteoporosis (OP) | Disease Subtypes | / | ||
| Organ | Bone | Test Sample / Technology Platform | Serum (fully automated chemiluminescence immunoassay analyzer, ELISA) | ||
| Pathobiological Mechanisms | The precursor fragments released by osteoblasts during type I collagen synthesis directly reflect the collagen synthesis rate and serve as a sensitive indicator of bone formation. | ||||
| Clinical Availability Status | Widely available | ||||
| Notes and Dynamics | Bone formation reference markers recommended by IOF/IFCC; an increase of ≥20% within 3 months post-treatment indicates the onset of anabolic drug (e.g., teriparatide) and is significantly associated with increased spinal BMD. | ||||