Parameter
| Biomarker | POSTN | Full name | Serum periostin | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | bone cortical metabolism | ||
| Disease | Osteoporosis (OP) | Disease Subtypes | / | ||
| Organ | Bone (Cortical bone) | Test Sample / Technology Platform | Serum (ELISA, immunohistochemistry) | ||
| Pathobiological Mechanisms | Primarily secreted by periosteal osteoblasts, it regulates collagen cross-linking and cortical bone strength. A decline in postmenopausal levels leads to increased cortical bone fragility. | ||||
| Clinical Availability Status | Scientific research verification | ||||
| Notes and Dynamics | It is independently associated with the risk of non-vertebral fractures (HR=1.89), particularly suitable for evaluating areas predominantly composed of cortical bone (e.g., hip); it holds promise as a periperal metabolic marker. | ||||