Parameter
| Biomarker | DKK-1 | Full name | serum Dickkopf-1 | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | inhibition of bone formation | ||
| Disease | Osteoporosis (OP) | Disease Subtypes | / | ||
| Organ | Bone | Test Sample / Technology Platform | Serum (ELISA, Western blot) | ||
| Pathobiological Mechanisms | Inhibition of Wnt pathway activity: In elderly patients, the decline in osteocyte function leads to increased secretion of DKK-1, which further suppresses osteogenesis. | ||||
| Clinical Availability Status | Research phase | ||||
| Notes and Dynamics | It is negatively correlated with lumbar BMD in elderly males (r=-0.42); teriparatide treatment can reduce its levels and reverse the state of bone formation inhibition. | ||||