Parameter
| Biomarker | S1P | Full name | Plasma sphingosine-1-phosphate | Molecular Type | lipid |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Regulation of osteocyte migration | ||
| Disease | Osteoporosis (OP) | Disease Subtypes | / | ||
| Organ | Bone, Bone marrow | Test Sample / Technology Platform | Plasma (LC-MS/MS, High Performance Liquid Chromatography HPLC) | ||
| Pathobiological Mechanisms | Regulation of osteoclast precursor migration via the S1PR1/S1PR2 pathway, elevated plasma S1P levels in elderly patients promote bone resorption, and imbalance of bone marrow-S1P gradient | ||||
| Clinical Availability Status | Research phase | ||||
| Notes and Dynamics | Elderly patients with S1P>3.5 μmol/L exhibit a 5.5-fold increased risk of hip fracture; the plasma/bone marrow ratio provides a more accurate assessment of bone resorption activity. | ||||