Parameter
| Biomarker | PBMC | Full name | peripheral blood monouclear cells | Molecular Type | microRNA |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Regulation of osteocyte differentiation | ||
| Disease | Osteoporosis (OP) | Disease Subtypes | / | ||
| Organ | Bone | Test Sample / Technology Platform | Peripheral blood PBMC (qRT-PCR、RNA-seq) | ||
| Pathobiological Mechanisms | Targeted inhibition of osteoblast transcription factor ATF4 and high expression of miR-133a in peripheral blood mononuclear cells (PBMCs) of elderly patients suppress osteogenic differentiation, exacerbating bone loss | ||||
| Clinical Availability Status | Research phase | ||||
| Notes and Dynamics | negatively correlated with lumbar BMD; it can serve as a potential molecular biomarker for the early diagnosis of senile osteoporosis | ||||