Parameter
| Biomarker | IGF-1 | Full name | Serum insulin-like growth factor-1 | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | bone formation regulation | ||
| Disease | Osteoporosis (OP) | Disease Subtypes | / | ||
| Organ | Bone | Test Sample / Technology Platform | Serum (Chemiluminescence, ELISA) | ||
| Pathobiological Mechanisms | Insulin resistance in diabetic patients leads to reduced IGF-1 synthesis, which inhibits osteoblast proliferation and collagen synthesis, thereby exacerbating bone loss. | ||||
| Clinical Availability Status | Clinically available (for auxiliary evaluation) | ||||
| Notes and Dynamics | It is positively correlated with lumbar BMD in diabetic patients; IGF-1 <100 ng/mL indicates impaired bone formation function and increased fracture risk. | ||||