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1211

Parameter
Biomarker LCN2 Full name Serum Lipid Carrier Protein 2 Molecular Type protein
Molecular Formula Molecular Weight Core Functional Dimensions Inflammation and bone metabolism
Disease Osteoporosis (OP) Disease Subtypes /
Organ Bone, Immune system Test Sample / Technology Platform Serum (ELISA, Western blot)
Pathobiological Mechanisms Diabetes-associated chronic inflammation induces LCN2 upregulation, which promotes osteoclast differentiation by activating the NF-κB pathway
Clinical Availability Status Research phase
Notes and Dynamics Can serve as an inflammatory biomarker for diabetic osteoporosis

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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