Parameter
| Biomarker | GSTP1 | Full name | Glutathione S-transferase P1 | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Oxidative stress and bone metabolism | ||
| Disease | Osteoporosis (OP) | Disease Subtypes | / | ||
| Organ | Bone | Test Sample / Technology Platform | Bone tissue (immunohistochemistry, Western blot) | ||
| Pathobiological Mechanisms | Participates in antioxidant stress, with reduced GSTP1 expression in the bone tissue of idiopathic patients, leading to increased ferroptosis of osteocytes and decreased bone strength. | ||||
| Clinical Availability Status | Research phase | ||||
| Notes and Dynamics | Positively correlated with iron accumulation in bone tissue, which may explain the mechanism of iron overload in idiopathic osteoporosis; its inhibitor can alleviate bone loss in mouse models. | ||||