Parameter
| Biomarker | PDFF | Full name | Proton Density Fat Fraction | Molecular Type | Imaging indicators (quantification of fat content) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Bone marrow adiposity assessment | ||
| Disease | Osteoporosis (OP) | Disease Subtypes | / | ||
| Organ | Bone (Vertebrae) | Test Sample / Technology Platform | Lumbar MRI (Multi-echo Chemical Shift Encoding MRI, mDixon technique) | ||
| Pathobiological Mechanisms | Osteoporosis patients exhibit increased bone marrow adipocytes, which compress hematopoietic and osteogenic spaces, with elevated PDFF indicating deterioration of the bone formation microenvironment. | ||||
| Clinical Availability Status | Clinical gradual promotion | ||||
| Notes and Dynamics | The PDFF in the osteoporosis/bone loss group was higher than that in the normal group; it was negatively correlated with lumbar BMD and could serve as a supplementary evaluation indicator for DXA. | ||||