Parameter
| Biomarker | miR-21 | Full name | serum microRNA association (miR-21+miR-23a+miR-125b) | Molecular Type | microRNA (multimarker panel) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Comprehensive regulation of bone metabolism | ||
| Disease | Osteoporosis (OP) | Disease Subtypes | / | ||
| Organ | Bone | Test Sample / Technology Platform | Serum (qRT-PCR, miRNA microarray) | ||
| Pathobiological Mechanisms | Collaboratively inhibits osteogenesis-related genes (e.g., RUNX2, BMP2) and promotes osteoclast-related genes (e.g., RANKL) expression, reflecting bone metabolic imbalance. | ||||
| Clinical Availability Status | Scientific research verification | ||||
| Notes and Dynamics | Combinatorial diagnosis of osteoporosis is significantly superior to single biomarkers; it enables dynamic monitoring of therapeutic efficacy. | ||||