Parameter
| Biomarker | RF | Full name | Rheumatoid Factor | Molecular Type | protein (IgM-class autoantibodies) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | diagnosis | ||
| Disease | Rheumatoid Arthritis (RA) | Disease Subtypes | / | ||
| Organ | Joint (Synovium, Cartilage, Bone) | Test Sample / Technology Platform | Serum (immunoturbidimetry, enzyme-linked immunosorbent assay (ELISA), electrochemical immunoassay platform) | ||
| Pathobiological Mechanisms | Targeting the Fc segment of IgG antibodies forms immune complexes, activates the complement system, and mediates synovial inflammation and joint tissue damage; it is positively correlated with disease activity indicators such as joint swelling and tenderness. | ||||
| Clinical Availability Status | Widely available | ||||
| Notes and Dynamics | 70%-80% of patients test positive, with a specificity of approximately 70%; the electrochemical platform enables simultaneous detection with other markers, reducing the assay time to within 2 hours. | ||||