Parameter
| Biomarker | anti-CCP | Full name | Anticyclopeptidin antibodies | Molecular Type | protein (autoantibody) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Early diagnosis, prognosis prediction | ||
| Disease | Rheumatoid Arthritis (RA) | Disease Subtypes | / | ||
| Organ | Joint (Synovium, Cartilage, Bone) | Test Sample / Technology Platform | Serum, synovial fluid (ELISA, chemiluminescence, electrochemical immunoassay) | ||
| Pathobiological Mechanisms | Identification of citrullinated protein antigens epitopes in synovial tissue, induction of immune cell activation and release of inflammatory factors, and promotion of osteoclast-mediated bone erosion; high titers indicate increased risk of joint destruction. | ||||
| Clinical Availability Status | Widely available | ||||
| Notes and Dynamics | The diagnostic specificity is 95%-98%, and it can be detected 3-5 years before the onset of the disease. | ||||