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1221

Parameter
Biomarker anti-CSP Full name Anticardiacine scavenger receptor A polypeptide antibody Molecular Type protein ( autoantibody )
Molecular Formula Molecular Weight Core Functional Dimensions Seronegative RA diagnosis and disease management
Disease Rheumatoid Arthritis (RA) Disease Subtypes /
Organ Joint (Synovium) Test Sample / Technology Platform Serum (ELISA)
Pathobiological Mechanisms The carboxylylated SR-A peptide exhibits aberrant glycosylation modifications, which can promote the secretion of inflammatory factors by chondrocyte-like organs, exacerbating synovial inflammation and bone destruction.
Clinical Availability Status Clinical trials
Notes and Dynamics Diagnostic sensitivity of 58.98% and specificity of 93.96%, indicating a potential therapeutic target.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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