Parameter
| Biomarker | APF | Full name | Antipolyadenylate factor | Molecular Type | protein ( autoantibody ) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Early seronegative RA diagnosis | ||
| Disease | Rheumatoid Arthritis (RA) | Disease Subtypes | / | ||
| Organ | Joint (Synovium) | Test Sample / Technology Platform | Serum (Indirect Immunofluorescence) | ||
| Pathobiological Mechanisms | Targeting the perinuclear antigen of buccal mucosal epithelial cells to activate T cell-mediated cellular immune responses can be detected in patients with RF and anti-CCP antibody negativity. | ||||
| Clinical Availability Status | Clinical auxiliary use | ||||
| Notes and Dynamics | The diagnostic specificity is approximately 90%, but the sensitivity is only40%-50%；Concomitant anti-keratin antibodies are required to enhance diagnostic accuracy | ||||