Parameter
| Biomarker | HLA-DRB1 alleles (e.g., HLA-DRB1*04/*01) | Full name | Human Leukocyte Antigen DRB1 alleles | Molecular Type | nucleic acid (genetic marker) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Genetic risk prediction | ||
| Disease | Rheumatoid Arthritis (RA) | Disease Subtypes | / | ||
| Organ | Immune system | Test Sample / Technology Platform | Blood (PCR-seq, gene chip) | ||
| Pathobiological Mechanisms | The RA core genetic susceptibility locus activates T cells by presenting self-antigens, with a familial contribution rate of approximately 60%. | ||||
| Clinical Availability Status | Research phase | ||||
| Notes and Dynamics | Individuals carrying the HLA-DRB1*04/*04 homozygote have a 5.8-fold higher risk of developing rheumatoid arthritis (RA) compared to the general population; this risk is further increased when combined with environmental factors. | ||||