Parameter
| Biomarker | microRNA (miR-146a、miR-155) | Full name | microRNA | Molecular Type | nucleic acid (non-coding RNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Inflammatory regulation, potential biomarkers | ||
| Disease | Rheumatoid Arthritis (RA) | Disease Subtypes | / | ||
| Organ | Joint (Synovium) | Test Sample / Technology Platform | Serum and synovial tissue (qRT-PCR, RNA-seq) | ||
| Pathobiological Mechanisms | miR-146a inhibits the TLR4/NF-κB pathway to negatively regulate inflammation, while miR-155 promotes Th17 cell differentiation; serum levels are associated with disease activity. | ||||
| Clinical Availability Status | Research phase | ||||
| Notes and Dynamics | It is expected to be developed as a novel therapeutic efficacy prediction biomarker, with the related detection kit currently in the preclinical validation stage. | ||||