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402

Parameter
Biomarker OCT3/4 Full name Octamer-binding Transcription Factor 3/4 Molecular Type Transcription factor (protein)
Molecular Formula / Molecular Weight / Core Functional Dimensions Diagnose, immunohistochemical markers for the identification of GCNIS, seminoma, and embryonal carcinoma.
Disease TGCT Disease Subtypes /
Organ Testis Test Sample / Technology Platform Tissue sections (immunohistochemistry)
Pathobiological Mechanisms The key factor that maintains the pluripotency and self-renewal of embryonic stem cells, the abnormal expression of which in adult testicular tissue is a marker of malignant transformation.
Clinical Availability Status Routine clinical pathology applications (gold standard tissue markers)
Notes and Dynamics Note: It is a core component of diagnostic pathology reports, but classified as an invasive examination.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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