Parameter
| Biomarker | MSLN (and SMRP) | Full name | Mesothelin (and Soluble Mesothelin-Related Protein) | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis,monitoring,potential therapeutic targets |
| Disease | Pleural Mesothelioma | Disease Subtypes | / | ||
| Organ | pleura | Test Sample / Technology Platform | Serum, pleural effusion (specific technology platform not specified) | ||
| Pathobiological Mechanisms | It is normally expressed in mesothelial cells such as pleura and participates in cell adhesion. It is highly expressed in PM, and its soluble fragment SMRP can be present in body fluids | ||||
| Clinical Availability Status | Widely used in clinical practice: As a common diagnostic marker for PM, it has limited specificity and needs to be judged comprehensively based on clinical, imaging, and pathological results | ||||
| Notes and Dynamics | 1. Elevated levels can also be seen in ovarian cancer, pancreatic cancer and benign pleural diseases; 2. It is a potential cancer treatment target; 3. Combined with hyaluronic acid, a two-step diagnostic model can be constructed, which can improve diagnostic accuracy | ||||