Parameter
| Biomarker | FBLN3 | Full name | Fibronectin-3 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis(controversial), potential therapeutic targets |
| Disease | Pleural Mesothelioma | Disease Subtypes | / | ||
| Organ | pleura | Test Sample / Technology Platform | Serum, plasma, pleural effusion(specific technology platform not specified) | ||
| Pathobiological Mechanisms | Involved in extracellular matrix composition, abnormally expressed in PM | ||||
| Clinical Availability Status | Study phase (diagnostic efficacy is controversial): Early studies showed high sensitivity and specificity (AUCROC 0.99), but subsequent studies failed to replicate the combined AUCROC of 0.91 | ||||
| Notes and Dynamics | 1. Not a reliable prognostic indicator of PM; 2. Not suitable for assessing the response of patients with PM to immunotherapy; 3. It has been proposed as a potential molecular target to delay the progression of PM, and related treatment methods are being explored. 4. The conclusion of the comparison with SMRP diagnostic efficacy is unclear | ||||