Parameter
| Biomarker | OPN | Full name | Osteopontin | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | diagnosis (low specificity), prognostic prediction |
| Disease | Pleural Mesothelioma | Disease Subtypes | / | ||
| Organ | pleura | Test Sample / Technology Platform | Serum (specific technology platform not specified) | ||
| Pathobiological Mechanisms | It is involved in cell adhesion, migration and other processes, and is highly expressed in PM, which is related to the degree of tumor malignancy | ||||
| Clinical Availability Status | Study stage (prognostic value is available, diagnostic value is limited): high accuracy in differentiating PM from healthy people (AUCROC 0.86 to 0.89), but not useful for differentiating PM from benign pleural effusion or other diseases | ||||
| Notes and Dynamics | 1. Low specificity, limiting its diagnostic application; 2. High levels of OPN in PM patients are associated with poor prognosis and have a potential prognostic predictive effect | ||||