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435

Parameter
Biomarker FCGRIB Full name FCGRIB gene Molecular Type Nucleic acids (DNA / transcriptome)
Molecular Formula / Molecular Weight / Core Functional Dimensions Diagnosis
Disease tuberculosis Disease Subtypes /
Organ Lung Test Sample / Technology Platform Whole blood (combined transcriptome and proteome test)
Pathobiological Mechanisms This gene is significantly upregulated after tuberculosis infection, and the combination with other genes can reflect the infection status
Clinical Availability Status Study validation: High sensitivity (94%) and specificity (97%) in small case-control studies
Notes and Dynamics Combined with LTF, guanylate binding protein 5, CD64, Granzyme A to distinguish active tuberculosis from latent tuberculosis infection (LTBI)

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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