Parameter
| Biomarker | p-tau (181,217,231) | Full name | Phosphorylated Tau (181,217,231) | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prognosis |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF/Plasma (SIMOA, IP-MS) | ||
| Pathobiological Mechanisms | Hyperphosphorylation of tau protein leads to neurofibrillary tangles, disrupting the neuronal cytoskeleton. p-tau is a direct product of this process. | ||||
| Clinical Availability Status | Clinical validation/guideline recommendation: CSF p-tau is a core biomarker for AD diagnosis; plasma p-tau217 exhibits excellent diagnostic performance. | ||||
| Notes and Dynamics | p-tau217 has higher specificity than p-tau181 and is a star molecule of next-generation blood biomarkers. | ||||