Parameter
| Biomarker | NfL | Full name | Neurofilament Light Chain | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Monitoring, Prognosis |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF/Plasma (SIMOA) | ||
| Pathobiological Mechanisms | A cytoskeletal protein released after axonal injury, serving as a non-specific marker of neuronal damage. | ||||
| Clinical Availability Status | Research/clinical monitoring tool: Widely used as an efficacy monitoring indicator in clinical trials; clinically used to assess the overall progression of neurodegenerative diseases. | ||||
| Notes and Dynamics | Elevated in various diseases such as AD, MS, and ALS, used to evaluate disease activity and treatment response. | ||||