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613

Parameter
Biomarker KLF4 Mut Full name KLF4 Gene Mutation Molecular Type Gene Mutation
Molecular Formula / Molecular Weight / Core Functional Dimensions Diagnosis, Prognosis
Disease Meningioma Disease Subtypes /
Organ Brain, Meninges Test Sample / Technology Platform Tumor Tissue (NGS, Immunohistochemistry)
Pathobiological Mechanisms Transcription factor mutation, co-occurs with TRAF7, regulates cell differentiation, and is associated with secretory subtypes.
Clinical Availability Status Under Clinical Validation
Notes and Dynamics Mainly located at the skull base, low recurrence rate, and its inhibitors can reduce tumor invasiveness.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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