Parameter
| Biomarker | SNAP-25 | Full name | Synaptosomal-Associated Protein 25 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Early Diagnosis |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF/Plasma (SIMOA, Mass Spectrometry) | ||
| Pathobiological Mechanisms | A key protein of the SNARE complex for synaptic vesicle fusion, released into CSF/plasma after synaptic injury, reflecting synaptic degeneration. | ||||
| Clinical Availability Status | Research validation: Elevated in the preclinical AD stage, positively correlated with Aβ pathology. | ||||
| Notes and Dynamics | Elevated in cognitively normal individuals with Aβ positivity, serving as an early sensitive indicator of synaptic degeneration. | ||||