Parameter
| Biomarker | GAP-43 | Full name | Growth-Associated Protein 43 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Disease Monitoring |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF (SIMOA, Immunoassay) | ||
| Pathobiological Mechanisms | A protein related to axonal regeneration and synaptic plasticity, released after synaptic injury, reflecting synaptic repair capacity. | ||||
| Clinical Availability Status | Research application: CSF levels in MCI patients progressing to AD are significantly higher than those in stable MCI. | ||||
| Notes and Dynamics | Positively correlated with Aβ-related tau accumulation, can be used as an indicator to assess AD progression rate. | ||||