Parameter
| Biomarker | TREM2/sTREM2 | Full name | Triggering Receptor Expressed on Myeloid Cells 2/Soluble TREM2 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Risk Stratification |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF/Plasma (Immunoassay, Electrochemiluminescence) | ||
| Pathobiological Mechanisms | A microglial activation receptor that regulates Aβ clearance and neuroinflammation; sTREM2 is its soluble form. | ||||
| Clinical Availability Status | Cutting-edge research: CSF sTREM2 peaks in the MCI stage, showing an "inverted U" curve. | ||||
| Notes and Dynamics | Carriers of the TREM2 R47H variant have a 3-4 fold increased risk of AD, which can be explored as a therapeutic target. | ||||