Parameter
| Biomarker | IBA-1 | Full name | Ionized Calcium-Binding Adapter Molecule 1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Risk Stratification |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Brain Biopsy/CSF (Immunohistochemistry, Immunoassay) | ||
| Pathobiological Mechanisms | A microglia-specific marker; expression increases after activation, involved in synaptic phagocytosis. | ||||
| Clinical Availability Status | Research application: IBA-1+ microglia aggregate around Aβ plaques in AD brains. | ||||
| Notes and Dynamics | Not yet used for peripheral testing, mainly as a pathological indicator in animal models and autopsy. | ||||