Parameter
| Biomarker | APP/PSEN1/PSEN2 DNA Meth | Full name | Amyloid Precursor Protein/Presenilin 1/Presenilin 2 DNA Methylation | Molecular Type | Nucleic Acid Modification |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Early Diagnosis |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Whole Blood/CSF (Bisulfite Sequencing, Methylation Microarray) | ||
| Pathobiological Mechanisms | Abnormal methylation of the promoters of APP, PSEN1, and PSEN2 genes regulates gene expression and affects Aβ production. | ||||
| Clinical Availability Status | Research exploration: APP promoter hypermethylation and PSEN1 promoter hypomethylation in AD patients | ||||
| Notes and Dynamics | Peripheral blood methylation patterns can reflect intracerebral pathology, with more significant abnormalities in familial AD. | ||||