Parameter
| Biomarker | Histone Mods (H3K9ac, H4K12ac, H3K27me3) | Full name | Histone Modifications (H3 Lysine 9 Acetylation, H4 Lysine 12 Acetylation, H3 Lysine 27 Trimethylation) | Molecular Type | Protein Modification |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Pathological Confirmation |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Brain Biopsy/CSF (ChIP-seq, Mass Spectrometry) | ||
| Pathobiological Mechanisms | Decreased H3K9ac/H4K12ac inhibits the expression of synapse-related genes; increased H3K27me3 silences neuroprotective genes. | ||||
| Clinical Availability Status | Research application: Levels of H3K9ac/H4K12ac are decreased in AD brains. | ||||
| Notes and Dynamics | Can be used as an indicator for AD pathobiological mechanism research, not yet used for clinical diagnosis. | ||||