Parameter
| Biomarker | miR-124/miR-132/miR-455-3p | Full name | MicroRNA-124/MicroRNA-132/MicroRNA-455-3p | Molecular Type | Non-coding RNA |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Early Diagnosis/Prognosis |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Plasma/CSF (qPCR, RNA-seq) | ||
| Pathobiological Mechanisms | miR-124 inhibits BACE1 expression to reduce Aβ production; miR-132 regulates tau phosphorylation; miR-455-3p is associated with synaptic function. | ||||
| Clinical Availability Status | Research exploration: Plasma miR-124 is decreased and miR-455-3p is elevated in AD patients. | ||||
| Notes and Dynamics | miR-455-3p can serve as a peripheral biomarker, negatively correlated with AD cognitive function. | ||||