Parameter
| Biomarker | lncRNA (BACE1-AS, MALAT1) | Full name | Long Non-Coding RNA (BACE1 Antisense RNA, Metastasis-Associated Lung Adenocarcinoma Transcript 1) | Molecular Type | Non-coding RNA |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Pathological Confirmation |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Plasma/CSF (RNA-seq, qPCR) | ||
| Pathobiological Mechanisms | BACE1-AS stabilizes BACE1 mRNA to promote Aβ production; MALAT1 regulates synaptogenesis. | ||||
| Clinical Availability Status | Research application: CSF BACE1-AS is elevated and MALAT1 is decreased in AD patients. | ||||
| Notes and Dynamics | Can be used as a target for AD pathobiological mechanism research, no clinical application yet. | ||||