Parameter
| Biomarker | SV2A (PET) | Full name | Synaptic Vesicle Protein 2A (PET Imaging) | Molecular Type | Protein (Imaging Biomarker) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Disease Monitoring |
| Disease | Alzheimer's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Brain ([11C] UCB-J/[18F] SynVesT-1 PET) | ||
| Pathobiological Mechanisms | A synaptic vesicle glycoprotein; PET imaging reflects synaptic density; reduced tracer binding due to synaptic loss in AD. | ||||
| Clinical Availability Status | Research application: SV2A binding rate is decreased in the hippocampus and temporal lobe of AD patients. | ||||
| Notes and Dynamics | Positively correlated with cognitive function, can intuitively assess the degree of synaptic injury. | ||||