Parameter
| Biomarker | α-Syn | Full name | α-Synuclein(Total α-syn) | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Early Diagnosis |
| Disease | Parkinson's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF/Plasma/Skin Biopsy (ELISA, SIMOA, WB) | ||
| Pathobiological Mechanisms | Abnormal aggregation forms Lewy bodies, disrupting the function of dopaminergic neurons. | ||||
| Clinical Availability Status | Research validation: Decreased CSF levels can distinguish PD from healthy individuals. | ||||
| Notes and Dynamics | Abnormal levels appear earlier in familial PD (SNCA mutation) patients. | ||||