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487

Parameter
Biomarker GFAP Full name Glial Fibrillary Acidic Protein Molecular Type Protein
Molecular Formula / Molecular Weight / Core Functional Dimensions Pathological Confirmation
Disease Parkinson's Disease Disease Subtypes /
Organ Brain Test Sample / Technology Platform Plasma/CSF (SIMOA, Immunoassay)
Pathobiological Mechanisms A marker of astrocyte activation, responding to α-syn pathology and neuroinflammation
Clinical Availability Status Research validation: Plasma levels in PD patients are 30% higher than those in healthy individuals.
Notes and Dynamics Can predict cognitive decline in PD.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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