Parameter
| Biomarker | GCase | Full name | Glucocerebrosidase | Molecular Type | Enzyme |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Risk Stratification |
| Disease | Parkinson's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Plasma/Leukocytes (Enzyme Activity Assay, Sequencing) | ||
| Pathobiological Mechanisms | GBA1 mutation leads to decreased enzyme activity, affecting α-syn clearance. | ||||
| Clinical Availability Status | Clinically available: GBA1 gene testing is used for risk assessment of familial PD. | ||||
| Notes and Dynamics | Enzyme activators can improve PD model pathology. | ||||