Parameter
| Biomarker | TNF-α | Full name | Tumor Necrosis Factor-α | Molecular Type | Cytokine |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Pathological Confirmation |
| Disease | Parkinson's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Serum/CSF (ELISA, Immunoassay) | ||
| Pathobiological Mechanisms | Activates microglia, inducing dopaminergic neuron apoptosis. | ||||
| Clinical Availability Status | Research validation: CSF levels in PD patients are positively correlated with substantia nigra neuron loss. | ||||
| Notes and Dynamics | Anti-TNF therapy can improve motor symptoms in PD models. | ||||