Parameter
| Biomarker | LRRK2 Mut (G2019S/R1441G) | Full name | LRRK2 Mutants (G2019S/R1441G) | Molecular Type | Nucleic Acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Risk Stratification |
| Disease | Parkinson's Disease | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Whole Blood (Gene Sequencing, PCR) | ||
| Pathobiological Mechanisms | Abnormal kinase activity leads to mitochondrial dysfunction and neuroinflammation. | ||||
| Clinical Availability Status | Clinical validation: A major pathogenic gene for familial PD. | ||||
| Notes and Dynamics | G2019S carriers can develop α-syn pathology 20 years in advance. | ||||