Parameter
| Biomarker | HMGB1 | Full name | High Mobility Group Box 1 Protein | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prediction |
| Disease | Epilepsy | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Serum/Cerebrospinal Fluid (ELISA, Western Blot) | ||
| Pathobiological Mechanisms | Acts as a damage-associated molecular pattern (DAMP) binding to TLR4, activates the NLRP3 inflammasome, promotes IL-1β release, and enhances NMDA receptor activity. | ||||
| Clinical Availability Status | Under clinical validation | ||||
| Notes and Dynamics | Serum HMGB1 levels are significantly elevated in drug-refractory TLE patients; anti-HMGB1 monoclonal antibodies can reduce seizures in animal models. | ||||