Parameter
| Biomarker | Aspartate Aminotransferase (AST) | Full name | Aspartate Aminotransferase | Molecular Type | Enzymes |
|---|---|---|---|---|---|
| Molecular Formula | Human AST: C₁₁₁₃H₁₇₆₁N₂₉₅O₃₃₅S₆ | Molecular Weight | ~121 kDa | Core Functional Dimensions | Assessment of liver injury, disease staging, and prognosis |
| Disease | Viral Hepatitis | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum | ||
| Pathobiological Mechanisms | It is widely distributed in liver, heart, muscle and other tissues, and is released into the blood when hepatocytes are injured. AST/ALT ratio > 1 indicates cirrhosis or severe liver injury, which is associated with liver cancer and all-cause mortality. It can assist in assessing the degree of liver fibrosis | ||||
| Clinical Availability Status | Routine clinical use | ||||
| Notes and Dynamics | The diagnostic value is slightly inferior to ALT, but combined with ALT and AST/ALT ratio can improve the ability to identify advanced liver disease, which is an important supplementary indicator for clinical comprehensive evaluation of liver health | ||||